• INDUS BMT GROUP

LIKELIHOOD OF FINDING A MATCH OUTSIDE FAMILY FOR PATIENTS

Updated: Aug 11, 2019


Gragert and colleagues in this study (goo.gl/Hys6Bw) report on probability of finding a suitable donor from NMDP adult donor and banked cord blood searches. Indians are included in category of South Asians. Whites (W), South Asians (SA)

  • NMDP has 10.5 million volunteer donors and 200,000 cord blood units listed

  • Adults donors: 8/8 allele match 75% (W), 33% (SA); 7/8 or better 97% (W), 84% (SA)

  • Cord blood units (5/6 or better match with 2.5E07/kg or more TNC): less than 20 y - 87% (W), 73% (SA); =/>20 y 66% (W), 41% (SA)

  • When a search is conducted, how often is the donor available (by donor ethnicity) - 51% (W), 29% (SA)

  • Bottom-line: The likelihood of finding a match with the use of a search strategy in which an 8/8 HLA-matched donor is sought first, then a 7/8 HLA-matched donor, and thereafter a cord-blood unit (4/6 or better) with an adequate cell dose is almost 100% for South Asians. goo.gl/l6NpuK


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